ALSBERG LAB PUBLICATIONS
2023
Tuftee C, Alsberg E, Ozbolat IT, Rizwan M. Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs. Trends in Biotechnology (in press 2023).
Hwang S-W, Lim C-M, Huynh CT, Moghimianavval H, Kotov NA, Alsberg E*, Liu AP*. Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation. Angewandte Chemie (in press 2023). *Co-corresponding authors.
Kang S-Y, Kimura M, Shrestha S, Lewis P, Lee S, Cai Y, Joshi P, Acharya P, Liu J, Yang Y, Sanchez JG, Ayyagari S, Alsberg E, Wells JM, Takebe T, Lee M-Y. A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis. Advanced Healthcare Materials (in press 2023).
Martyniak K, Cruz MA, Kennedy S, Karimzadeh M, Jeon O, Alsberg E, Kean TJ. Optimizing bioink composition for human chondrocyte expression of lubricin. Bioengineering (in press 2023).
Hsu Y-Y, Hwang S-W, Chen SJ, Alsberg E, Liu AP. Development of mechanosensitive synthetic cells for biomedical applications. SLAS Technology (in press 2023).
Hassan S, Wang T, Shi K, Huang Y, Urbina M, Gan K, Chen M, Willemen N, Kalam H, Luna-Ceron E, Cecen B, Elbait GD, Li J, Garcia-Rivera LE, Gurian M, Banday MM, Yang K, Lee MC, Zhuang W, Johnbosco C, Jeon O, Alsberg E, Leijten J, Shin SR. Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells. Biomaterials (in press 2023).
Margolis EA, Friend NE, Rolle MW, Alsberg E, Putnam AJ. Manufacturing the Multiscale Vascular Hierarchy: Progress Towards Solving Tissue Engineering’s Grand Challenge. Trends in Biotechnology (in press 2023).
Habib M, Hussien S, Jeon O, Lotz JC, Wu P I-K, Alsberg E, Fields AJ. Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition. Frontiers in Bioengineering and Biotechnology (in press, 2023).
Tang R, Gasvoda K, Alsberg E. Protein conformation stabilized by newly formed turns for thermal resilience. Biophysical Journal, 122(1): 82-89, 2023.
2022
Lee J, Jeon O, Koh J, Kim H-J, Lee SJ, Zhu Y, Song J, Lee Y, Nasiri R, Lee K, Bandaru P, Cho H-J, Zhang S, Barros NR, Ahadian S, Kang H, Dokmeci MR, Lee J, Di Carlo D, Alsberg E*, Khademhosseini A*. Micromechanical property mismatch between pericellular and extracellular matrices regulates stem cell articular and hypertrophic chondrogenesis. Matter (in press, 2022). *Co-corresponding authors.
Ding A, Lee SJ, Tang R, Gasvoda KL, He Felicia, Alsberg E. 4D cell-condensate bioprinting. Small, 18(36), e2202196, 2022. Yazdanpanah G, Shen X, Nguyen T, Anwar KN, Jeon O, Jiang Y, Pachenari M, Pan Y, Shokuhfar T, Rosenblatt MI, Alsberg E, Djalilian AR. A tunable extracellular matrix hydrogel for in-situ suture-free corneal repair. Advanced Functional Materials, 32(24): 2113383, 2022.
Ding A, Jeon O, Cleveland D, Gasvoda KL, Wells D, Lee SJ, Alsberg E. Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting. Adv Mater. 2022 Jan 22:e2109394.
Ding A, Lee SJ, Ayyagari S, Tang R, Huynh CT, Alsberg E. 4D biofabrication via instantly generated graded hydrogel scaffolds. Bioactive materials. 2022 Jan 1;7:324-32.
2021
Jeon O, Lee YB, Lee SJ, Guliyeva N, Lee J, Alsberg E. Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries. Bioactive Materials. 2021 Dec 22.
Jeon O, Kim TH, Alsberg E. Reversible dynamic mechanics of hydrogels for regulation of cellular behavior. Acta Biomaterialia. 2021 Dec 1;136:88-98.
Freeman FE, Pitacco P, Van Dommelen LH, Nulty J, Browe DC, Shin JY, Alsberg E, Kelly DJ. Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects. Bio-protocol. 2021 Nov 5;11(21):e4219-.
Lee YB, Jeon O, Lee SJ, Ding A, Wells D, Alsberg E. Induction of Four‐Dimensional Spatiotemporal Geometric Transformations in High Cell Density Tissues via Shape‐Changing Hydrogels. Advanced Functional Materials. 2021 Jun;31(24):2010104.
Ding A, Jeon O, Tang R, Lee YB, Lee SJ, Alsberg E. Cell‐Laden Multiple‐Step and
Reversible 4D Hydrogel Actuators to Mimic Dynamic Tissue Morphogenesis. Advanced Science. 2021 May;8(9):2004616.
Nulty J, Freeman FE, Browe DC, Burdis R, Ahern DP, Pitacco P, Lee YB, Alsberg E, Kelly DJ. 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects. Acta Biomaterialia. 2021 May 1;126:154-69.
McMillan A, Nguyen MK, Huynh CT, Sarett SM, Ge P, Chetverikova M, Nguyen K, Grosh D, Duvall CL, Alsberg E. Hydrogel microspheres for spatiotemporally controlled delivery of RNA and silencing gene expression within scaffold-free tissue engineered constructs. Acta Biomaterialia. 2021 Apr 1;124:315-26.
Tang R, Gasvoda K, Rabin J, Alsberg E. Transforming growth factor-β1 is resilient to heat-induced conformational change. Biological and Medicinal Chemistry. 2021 Mar
2020
Herberg S, Varghai D, Alt DS, Dang PN, Park H, Cheng Y, Shin JY, Dikina AD, Boerckel JD, Rolle MW, Alsberg E. Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration. Communications biology. 2021 Jan 19;4(1):1-6.
Tang R, Umemori K, Rabin J, Alsberg E. Bifunctional Nanoparticle‐Stabilized Hydrogel Colloidosomes Serve as both Extracellular Matrix and Bioactive Factor Delivery Vehicles. Advanced therapeutics. 2020 Nov;3(11):2000156.
Freeman FE, Pitacco P, van Dommelen LH, Nulty J, Browe DC, Shin JY, Alsberg E, Kelly DJ. 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration. Science Advances. 2020 Aug 1;6(33):eabb5093.
Sattayaprasert P, Vasireddi SK, Bektik E, Jeon O, Hajjiri M, Mackall JA, Moravec CS, Alsberg E, Fu J, Laurita KR. Human Cardiac Mesenchymal Stem Cells Remodel in Disease and Can Regulate Arrhythmia Substrates. Circulation: Arrhythmia and Electrophysiology. 2020 Jun 23.
Critchley S, Sheehy EJ, Cunniffe G, Diaz-Payno P, Carroll SF, Jeon O, Alsberg E, Brama PA, Kelly DJ. 3D printing of fiber-reinforced cartilaginous templates for the regeneration of osteochondral defects. Acta Biomaterialia. 2020 Jun 4.
Lee J, Jeon O, Kong M, Abdeen AA, Shin JY, Lee HN, Lee YB, Sun W, Bandaru P, Alt DS, Lee K, Kim HJ, Lee SJ, Chaterji S, Shin SR, Alsberg E, Khademhosseini A. Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell–based cartilage tissue engineering. Science Advances. 2020 May 1;6(21):eaaz5913.
Hung BP, Gonzalez-Fernandez T, Lin JB, Campbell T, Lee YB, Panitch A, Alsberg E, Leach JK. Multi-peptide presentation and hydrogel mechanics jointly enhance therapeutic duo-potential of entrapped stromal cells. Biomaterials. 2020 Mar 20:119973.
2019
de Melo BA, Jodat YA, Mehrotra S, Calabrese MA, Kamperman T, Mandal BB, Santana MH, Alsberg E, Leijten J, Shin SR. 3D Printed Cartilage‐Like Tissue Constructs with Spatially Controlled Mechanical Properties. Advanced Functional Materials. 2019 Dec;29(51):1906330.
Khalil AS, Yu X, Dang PN, Alsberg E, Murphy WL. A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates. Acta Biomaterialia. 2019 Sep 1;95:408-17.
Nguyen MK, Huynh CT, Gilewski A, Wilner SE, Maier KE, Kwon N, Levy M, Alsberg E. Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing. Science Advances. 2019 Aug 1;5(8):eaax0801.
Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin JY, McMillan A, Dikina AD, He F, Lee YB, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD, Alsberg E. Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair. Science Advances. 2019 Aug 1;5(8):eaax2476.
McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science Translational Medicine. 2019 Jun 5;11(495).
Jeon O, Lee YB, Hinton TJ, Feinberg AW, Alsberg E. Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues. Materials Today Chemistry. 2019 Jun 1;12:61-70.
Kudva AK, Dikina AD, Luyten FP, Alsberg E, Patterson J. Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture. Acta Biomaterialia. 2019 May 1;90:287-99.
Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TL, Kelly DJ. Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells. Acta Biomaterialia. 2019 Apr 1;88:314-24.
Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR. Nonadhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids. Stem Cell Reports. 2019 Feb 12;12(2):381-94.
Critchley S, Cunniffe G, O'Reilly A, Diaz-Payno P, Schipani R, McAlinden A, Withers D, Shin J, Alsberg E, Kelly DJ. Regeneration of osteochondral defects using developmentally inspired cartilaginous templates. Tissue Engineering Part A. 2019 Feb 1;25(3-4):159-71.
Jeon O, Lee YB, Jeong H, Lee SJ, Wells D, Alsberg E. Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineered tissues with complex geometries. Materials Horizons. 2019;6(8):1625-31.
2018
Strobel HA, Qendro EI, Alsberg E, Rolle MW. Targeted delivery of bioactive molecules for vascular intervention and tissue engineering. Frontiers in pharmacology. 2018 Nov 21;9:1329.
Strobel HA, Hookway TA, Piola M, Fiore GB, Soncini M, Alsberg E, Rolle MW. Assembly of tissue-engineered blood vessels with spatially controlled heterogeneities. Tissue Engineering Part A. 2018 Oct 1;24(19-20):1492-503.
Nguyen MK, Jeon O, Dang PN, Huynh CT, Varghai D, Riazi H, McMillan A, Herberg S, Alsberg E. RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomaterialia. 2018 Jul 15;75:105-14.
Huynh CT, Liu F, Cheng Y, Coughlin KA, Alsberg E. Thiol-epoxy “Click” chemistry to engineer cytocompatible PEG-based hydrogel for siRNA-mediated osteogenesis of hMSCs. ACS Applied Materials & Interfaces. 2018 Jul 9;10(31):25936-42.
Jeon O, Lee K, Alsberg E. Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location‐Specific Regulation of Cellular Behaviors. Small. 2018 Jun;14(25):1800579.
Wong SA, Rivera KO, Miclau III T, Alsberg E, Marcucio RS, Bahney CS. Microenvironmental regulation of chondrocyte plasticity in endochondral repair—a new frontier for developmental engineering. Frontiers in Bioengineering and Biotechnology. 2018 May 15;6:58.
Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E. A modular strategy to engineer complex tissues and organs. Advanced Science. 2018 May;5(5):1700402.
Wang S, Bruning A, Jeon O, Long F, Alsberg E, Choi CK. An in-situphotocrosslinking microfluidic technique to generate non-spherical, cytocompatible, degradable, monodisperse alginate microgels for chondrocyte encapsulation. Biomicrofluidics. 2018;12(1):014106.
Herberg S, Varghai D, Cheng Y, et al. High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue. Nanotheranostics. 2018;2(2):128-143.
Seo J, Shin JY, Leijten J, Jeon O, Bal ÖA, Rouwkema J, Li Y, Shin S, Hajiali H, Alsberg E*, Khademhosseini E*: Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three-dimensions. ACS Applied Materials & Interfaces (in press, 2018). *Co-corresponding authors.
Seo J, Shin JY, Leijten J, Jeon O,Camci-Unal G, Dikina AD, Brinegar K, Ghaemmaghami AM, Alsberg E*, Khademhosseini A*: High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153: 85-101-255, 2018. *Co-corresponding authors.
McMillan A, Nguyen MK, Gonzalez-Fernandez T, Ge P, Yu X, Murphy WL, Kelly DJ, Alsberg E: Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials, 161: 240-255, 2018.
Wang S, Bruning A, Jeon O, , Long F, Alsberg E, Choi CK: An in-situ photocrosslinking microfluidic technique to generate non-spherical, cytocompatible, degradable, monodisperse alginate microgels for chondrocyte encapsulation. Biomicrofluidics, 12(1):014106, 2018.
2017
Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E: A modular strategy to engineer complex tissues and organs. Advanced Science (in press, 2017).
Jeon O, Shin JY, Marks R, Hopkins M, Kim TH, Park H, Alsberg E: Highly elastic and tough interpenetrating polymer network-structured hybrid hydrogels for cyclic mechanical loading-enhanced tissue engineering. Chemistry of Materials (in press, 2017).
Radisic M, Alsberg E: Special Issue on Tissue Engineering. ACS Biomaterials Science and Engineering, 3(9): 1880-1883, 2017.
Dang PN, Herberg S, Varghai D, Riazi H, Varghai D, McMillan A, Awadallah A, Phillips LM, Jeon O, Nguyen MK, Dwivedi N, Yu X, Murphy WL, Alsberg E: Endochondral ossification in critical-sized bone defects via readily implantable scaffold-free stem cell constructs. Stem Cells Translational Medicine, 6(7): 1644-1659, 2017.
Marcucio RS, Qin L, Alsberg E, Boerckel JD: Reverse engineering development: crosstalk opportunities between developmental biology and tissue engineering. Journal of Orthopaedic Research, 35(11): 2356-2368, 2017.
Dikina AD, Lai BP, Cao M, Zborowski M, Alsberg E: Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets. Biomaterials Science, 5(7): 1241-1245, 2017.
Gelberman RH, Linderman SW, Jayaram R, Dikina AD, Sakiyama-Elbert S, Alsberg E, Thomopolous S, Shen H: Combined administration of ASCs and BMP12 promotes an M2 macrophage phenotype and enhances regeneration in tendon repair. Clinical Orthopaedics and Related Research, 475(9), 2318-2331, 2017.
Almeida H, Dikina A, Mulhall K, O'Brien F, Alsberg E, Kelly, D: Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells. ACS Biomaterials Science and Engineering, 3(6): 1075-1082, 2017.
Cunniffe GM, Gonzalez-Fernandez T, Daly A, Sathy BN, Jeon O, Alsberg E, Kelly DJ: 3D Bioprinting of PCL Reinforced Gene Activated Bioinks for Bone Tissue Engineering Tissue Engineering, Part A, 23(17-18): 891-900, 2017.
Dikina AD, Almeida HV, Cao M, Kelly DJ, Alsberg E: Scaffolds derived from ECM produced by chondrogenically-induced human MSC condensates support human MSC Chondrogenesis. ACS Biomaterials, 3(7): 1426-1436, 2017. Invited for special themed issue “Biomimetic Bioactive Materials: The Next Generation of Implantable Devices.”
Strobel HA, Dikina AD, Levi K, Solorio LD, Alsberg E, Rolle MW: Cellular self-assembly with microsphere incorporation for growth factor delivery within engineered vascular rings. Tissue Engineering A, 23(3-4): 143-155, 2017.
Fu AS, Solorio LD, Alsberg E, Saidel GM: Mathematical modeling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres. Journal of Tissue Engineering and Regenerative Medicine, 11(2): 481-488, 2017.
Sathy BN, Olvera D, Gonzalez-Fernandez T, Cunniffe GM, Pentlavalli S, Chambers P, Jeon O, Alsberg E, McCarthy HO, Dunne N, Donahue TLH, Kelly DJ: RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo. Journal of Material Chemistry B, 5:1753-1764, 2017.
Huynh CT, Zheng Z, Nguyen MK; McMillan A, Tonga GY, Rotello V, Alsberg E: Cytocompatible Catalyst-free Photodegradable Hydrogels for Light-Mediated RNA Release to Induce hMSC Osteogenisis. ACS Biomaterials Science and Engineering, 3(9): 2011-2023. Invited for special themed issue “Tissue Engineering.”
Nguyen MK, McMillan A, Schapira DS, Alsberg E: Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation. Journal of Material Chemistry B, 5: 485-495, 2017. Invited for special themed issue “Bio-inspired and Natural Materials.”
2016
Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA, Leach JK: Bone morphogenetic protein-2 promotes human mesenchymal stem cell survival and resultant bone formation when entrapped in photocrosslinked alginate hydrogels. Advanced Healthcare Materials, 5(19): 2501-2509, 2016.
Huynh CT, Nguyen MK, Tonga GY, Longe L, Rotello VM, Alsberg E: Photocleavable hydrogels for light-triggered siRNA release. Advanced Healthcare Materials, 5(3):305-10, 2016. Highlighted as cover.
Verrier S, Alini M, Alsberg E, Buchman SR, Kelly D, Laschke MW, Menger MD, Murphy WL, Stegemann JP, Schutz M, Miclau T, Stoddart MJ, Evans C: Tissue engineering and regenerative approaches to improving the healing of large bone defects. eCells and Materials, 32:87-110, 2016.
Carlier A, Alsberg E: Harnessing topographical cures for tissue engineering. Tissue Engineering A, 22(15-16): 995-6, 2016.
Daly AC, Cunniffe GM, Sathy BN, Jeon O, Alsberg E, Kelly DJ: 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering. Advanced Healthcare Materials, 5(18): 2353-62, 2016.
Huynh CT, Nguyen MK, Naris M, Tonga GY, Rotello VM, Alsberg E: Light-Triggered RNA Release and Induction of hMSC Osteogenesis via Photodegradable, Dual-Crosslinked Hydrogels. Nanomedicine, 11(12): 1535-50, 2016.
Jeon O, Marks R, Wolfson D, Alsberg E: Dual-crosslinked hydrogel microwell system for formation and culture of multicellular human adipose-derived stem cell spheroids. Journal of Material Chemistry B, 4: 3526-3533, 2016. Highlighted as inside front cover.
Samorezov JE, Headley EB, Everett CR, Alsberg E: Sustained presentation of BMP-2 enhances osteogenic differentiation of human adipose-derived stem cells in gelatin hydrogels. Journal of Biomedical Materials Research-A, 104(6):1387-97, 2016.
Wang S, Jeon O, Shankles PG, Liu Y, Alsberg E, Retterer ST, Lee BP, Choi CK: In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel. Biomicrofluidics, 10(1):011101, 2016.
Dang PN, Dwivedi N, Yu X, Phillips L, Bowerman C, Murphy W, Alsberg E: Guiding chondrogenesis and osteogenesis with mineral-coated hydroxyapatite and BMP-2 incorporated within high-density hMSC aggregates for bone regeneration. ACS Biomaterials, 2(1): 30-42, 2016. Highlighted as cover.
Dang PN, Dwivedi N, Phillips L, Yu X, Herberg S, Bowerman C, Solorio LD, Murphy WL, Alsberg E: Controlled growth factor delivery from microparticles incorporated within hMSC aggregates for enhanced bone tissue engineering via endochondral ossification. Stem Cells Translational Medicine, 5(2) 206-17, 2016.
Huynh CT, Nguyen MK, Tonga GY, Longe L, Rotello VM, Alsberg E: Photocleavable hydrogels for light-triggered siRNA release. Advanced Healthcare Materials, 5(3):305-10, 2016. Highlighted as cover.
2015
Solorio LD, Phillips LM, McMillan A, Cheng CW, Dang PN, Samorezov JE, Alsberg E: Spatially Organized Differentiation of Mesenchymal Stem Cells within Biphasic Microparticle-Incorporated High Cell Density Osteochondral Tissues. Advanced Healthcare Materials, 4(15):2306-13, 2015.
Samorezov JE, Morlock CM, Alsberg E: Dual ionic and photocrosslinked alginate hydrogels for micropatterned spatial control of material properties and cell behavior. Bioconjugate Chemistry, 26(7): 1339-47, 2015. Invited for special issue “Biofunctional Biomaterials – The 3rd Generation of Medical Devices.”
Dikina AD, Strobel HA, Lai BP, Rolle MW, Alsberg E: Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs. Biomaterials, 52: 452-62, 2015.
Jeon O, Wolfson DW, Alsberg E: In situ forming growth factor-loaded coacervate microparticle-embedded hydrogel for directing encapsulated stem cell fate. Advanced Materials, 27(13) 2216-23, 2015. Highlighted as Frontispiece.
Hill MC, Nguyen MK, Jeon O, Alsberg E: Spatial control of cell gene expression by siRNA gradients in biodegradable hydrogels. Advanced Healthcare Materials, 4(5): 714-22, 2015. Highlighted as Back Cover.
Samorezov JE, Alsberg E: Spatial regulation of controlled bioactive factor delivery for bone tissue engineering. Advanced Drug Delivery Reviews, 84: 45-67, 2015.
2014
Boerckel JD, Mason DE, McDermott AM, Alsberg E: Microcomputed tomography: Approaches and applications in bioengineering. Stem Cell Research & Therapy, 5(6): 144, 2014.
Jeong SI, Burns NA, Bonino CA, Kwon IK, Khan SA, Alsberg E: Improved cell infiltration of highly porous 3D nanofibrous scaffolds formed by combined fiber-fiber charge repulsions and ultra-sonication. Journal of Materials Chemistry B, 2(46): 8116-8122, 2014.
Nguyen K, Jeon O, Krebs MD, Alsberg E: Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation. Biomaterials, 35(24): 6278-86, 2014.
Dang PN, Solorio LD, Alsberg E: Driving cartilage formation in high-density human adipose-derived stem cell aggregate and sheet constructs without exogenous growth factor delivery. Tissue Engineering A, 20(23-24): 3163-75, 2014.
Yu X, Dang PD, Alsberg E, Murphy WL: Multilayer inorganic microparticles for tunable dual growth factor delivery. Advanced Functional Materials, 24(20): 3082-3093, 2014.
Nguyen K, Alsberg E: Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine. Progress in Polymer Science, 39(7): 1236-1265, 2014.
Cheng C, Solorio LD, Alsberg E: Decellularized tissues for orthopaedic tissue engineering. Biotechnology Advances, 32(2):462-84, 2014.
Panda NC, Zuckerman ST, Mesubi OO, Rosenbaum DS, Penn MS, Donahue JK, Alsberg E, Laurita KR: Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. J Interv Card Electrophysiol., 41(2):117-27, 2014.
Jeon O, Samorezov J, Alsberg E: Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications. Acta Biomaterialia, 10(1):47-55, 2014.
Andersen T, Markussen C, Dornish M, Heier-Baardson H, Melvik JE, Alsberg E, Christensen BE: In situ gelation for cell immobilization and culture in alginate foam scaffolds. Tissue Engineering, Part A, 20(3-4)600-10, 2014.
Andersen T, Melvik J, Gåserød O, Alsberg E, Christensen B: Ionically gelled alginate foams: Physical properties controlled by type, amount and source of gelling ions. Carbohydrate Polymers, 99:249-56, 2014.
Heylman CM, Santosa S, Krebs MD, Saidel GM, Alsberg E, Muschler GF: Modeling and experimental methods to predict optimal oxygen distribution for tissue regeneration in bone defects Medical and Biological Computing and Engineering, 52(4):321-30, 2014.
2013
Jeon O, Alt D, Ahmed SM, Linderman S, Alsberg E: Biochemical and physical signal gradients in hydrogels to control stem cell behavior. Advanced Materials, 25(44):6366-72, 2013.
Jeon O, Alsberg E: Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system. Advanced Functional Materials, 23(38):4765-75, 2013.
Saquing C, Tang C, Monian B, Bonino C, Manasco J, Alsberg E, Khan S: Alginate-PEO blend nanofibers and the role of carrier polymer in electrospinning. Industrial & Engineering Chemistry Research, 52(26):8692-8704, 2013.
Jeon O, Alsberg E: Photofunctionalization of alginate hydrogels to promote adhesion and proliferation of human mesenchymal stem cells. Tissue Engineering, Part A, 19(11-12):1424-32, 2013.
Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z: Imaging early stage osteogenic differentiation of mesenchymal stem cells. Journal of Orthopaedic Research, 31(6):871-9, 2013.
Solorio L, Vieregge E, Dhami C, Alsberg E: High density cell systems incorporating polymer microspheres as microenvironmental regulators in engineering cartilage tissues. Tissue Engineering, Part B, 19(3):209-20, 2013.
Nguyen K, Dang PN, Alsberg E: Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells. Acta Biomaterialia, 9(1): 4487-4495, 2013.
2012
Andersen T, Melvik J, Gåserød O, Alsberg E, Christensen B: Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters. Biomacromolecules, 13(11): 3703-3710, 2012.
Jeong SI, Jeon O, Krebs MD, Hill MC, Alsberg E: Biodegradable photocrosslinked alginate nanofiber scaffolds with tunable physical properties, cell adhesivity, and growth factor release. eCells and Materials, 24: 331-343, 2012.
Solorio LD, Vieregge EL, Dhami CD, Alsberg: Spatiotemporal regulation of chondrogenic differentiation with controlled delivery of TGF-β1 from gelatin microspheres in mesenchymal stem cell aggregates. Stem Cells Translational Medicine, 1(8): 632-639, 2012.
Chim H, Miller E, Gliniak C, Alsberg E: Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding. Cell and Tissue Research, 350(1): 89-94, 2012.
Bonino CA, Efimenko K, Jeong SI, Krebs MD, Alsberg E, Khan SA: Three-Dimensional Electrospun Alginate Mats via Tailored Charge Repulsions. Small, 8(12): 1928-36, 2012.
Jeon O, Alt D, Ahmed SM, Alsberg E: The effect of oxidation on the degradation of photocrosslinkable alginate hydrogels. Biomaterials, 33(13): 3503-3514, 2012.
Solorio LD, Vieregge EL, Dhami CD, Dang PN, Alsberg E: Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing chondrogenic growth factor. Journal of Controlled Release, 158(2): 224-232, 2012.
Lee Z, Dennis J, Alsberg E, Krebs MD, Welter J, Caplan A: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol., 506:247-63, 2012.
2011
Bonino CA, Samerozev JE, Jeon O, Alsberg E, Khan SA: Real-time in situ rheology of alginate hydrogel photocrosslinking. Soft Matter, 7(24): 11510-11517, 2011.
Lee JB, Jeong SI, Bae MS, Heo DN, Kim CH, Alsberg E, Kwon IK: Highly porous electrospun nanofibers enhanced by ultra-sonication for improved cellular infiltration. Tissue Engineering Part A, 17(21-22): 2695-2702, 2011.
Jeon O, Powell C, Solorio L, Krebs MD, Alsberg E: Affinity-based growth factor delivery from biodegradable, photocrosslinked heparin-alginate hydrogels.Journal of Controlled Release, 154(3): 258-266, 2011.
Bonino CA, Krebs MD, Saquing CD, Jeong SI, Shearer KL, Alsberg E, Khan SA: Electrospinningalginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems. Carbohydrate Polymers, 85(1): 111-119, 2011.
Jeon O, Krebs MD, Alsberg E: Controlled and sustained gene delivery from injectable porous PLGA scaffolds. Journal of Biomedical Materials Research-A,98A(1): 72-79, 2011.
Krebs MD, Alsberg E: Localized, Targeted and Sustained Silencing RNA Delivery.Chemistry - A European Journal,17(11): 3054-3062, 2011.
Jeong SI, Krebs MD, Bonino CA, Samorezov JE, Khan SA, Alsberg E: Electrospun chitosan-alginate nanofibers with in situ polyelectrolyte complexation for use as tissue engineering scaffolds. Tissue Engineering: Part A, 17(1-2): 59-70, 2011.
2010
Sasaki JI, Asoh TA, Matsumoto T, Egusa H, Yatani H, Akashi M, Alsberg E, Sohmura T: Fabrication of 3D cell constructs using temperature-responsive hydrogel. Tissue Engineering: Part A, 16(8): 2497-2504, 2010.
Jeon O, Powell C, Ahmed SM, Alsberg E: Biodegradable, photocrosslinked alginate hydrogels with independently tailorable physical properties and cell adhesivity. Tissue Engineering: Part A, 16(9): 2915-2925, 2010.
Jeong SI, Krebs MD, BoninoCA, KhanSA, AlsbergE: Electrospun alginate nanofibers with controlled cell adhesion for tissue engineering. Macromolecular Biosciences, 10(8): 934-943, 2010.
Solorio LD, Fu AS, Hernandez-Irizarry R, Alsberg E: Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-b1 from incorporated polymer microspheres. Journal of Biomedical Materials Research-A, 92(3): 1139-1144, 2010.
Krebs MD, Salter E, Chen E, Sutter KA, Alsberg E: Calcium phosphate-DNA nanoparticle gene delivery from alginate hydrogels induces in vivo osteogenesis.Journal of Biomedical Materials Research-A, 92(3): 1131-1138, 2010.
2009
Erb RM, Krebs MD, Alsberg Em Samata B, Rotello VM, Yellen BB: Beyond diffusion-limited aggregation kinetics in microparticle suspensions. Physical Review E, 80(5 Pt 1), 2009.
Krebs MD, Jeon O, Alsberg E: Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels. Journal of the American Chemical Society, 131(26): 9204-9206, 2009.
Krebs MD, Erb RM, Yellen BB, Samanta B, Bajaj A, Rotello VM, Alsberg E: Formation of
ordered cellular structures in suspension via label-free negative magnetophoresis. Nanoletters, 9(5): 1812-1817, 2009.
Krebs MD, Sutter K, Lin AS, Guldberg RE, Alsberg E: Injectable poly(lactic-co-glycolic) acid scaffolds with in situ pore formation for tissue engineering. ActaBiomaterialia, 5(8): 2847-2759, 2009.
Jeon O, Mansour JM, Alsberg E: Photocrosslinkable alginate hydrogels with tunable biodegradation rates and mechanical properties. Biomaterials, 30(14): 2724-2734, 2009.
2008
Grikscheit TC, Sala FG, Ogilvie J, Bower KA, Ochoa ER, Alsberg E, Mooney DJ, Vacanti JP: Tissue-engineered spleen protects against overwhelming pneumococcal sepsis in a rodent model. Journal of Surgical Research, 149(2): 214-218, 2008.
2007
Matsumoto T, Sasaki JI, Alsberg E, Egusa H, Yatani H, Sohmura T: Three-dimensional cell and tissue patterning in a strained fibrin gel system. PLoS ONE,2(11): e1211, 2007.
2006
Alsberg E, von Recum HA, Mahoney MJ. Environmental cues to guide stem cell fate decision for tissue engineering applications. Expert Opinion on Biological Therapy, 6(9):847-866, 2006.
Alsberg E, Feinstein E, Joy MP, Prentiss M, Ingber DE: Magnetically-guided self-assembly of fibrin matrices with ordered nanoscale structure for tissue engineering. Tissue Engineering, 12(11): 3247-3256, 2006. (Chosen for cover)
Xia S, Hunt TP, Mayers BT, Alsberg E, Whitesides GM, Westervelt R, Ingber DE. Combined micromagnetic-microfluidic separation of living cells in continuous flow. Biomed. Microdevices, 8(4): 299-308, 2006.
2005
Overby DR, Matthews BD, Alsberg E, Ingber DE: Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomaterialia, 1(3): 295-303, 2005.
Lee H, Liu Y, Alsberg E, Ingber DE, Westervelt RM, Ham D: An IC/microfluidic hybrid microsystem for 2D magnetic manipulation of individual biological cells.IEEE Int. Solid State Circuits, 80-81, 2005.
Kong HJ, Polte TR, Alsberg E, Mooney DJ: FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proceedings of the National Academy of Sciences, 102(12): 4300-4305, 2005.
Moore KA, Polte T, Huang S, Shi B, Alsberg E, Sunday ME, Ingber DE: Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Developmental Dynamics, 232(2): 268-281, 2005.
2004
Lee KY*, Alsberg E*, Hsiong S, Mooney DJ: Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation. Nanoletters, 4(8): 1501-1506, 2004. *Shared first authorship.
Kong HJ, Alsberg E, Kaigler D, Lee KY, Mooney DJ: Controlling degradation of hydrogels via size of crosslinked junctions. Advanced Materials, 16(21): 1917-1921, 2004.
Grimmer JF, Gunnlaugsson CB, Alsberg E, Murphy HS, Kong HJ, Mooney DJ, Weatherly RA: Tracheal reconstruction using tissue-engineered cartilage.Archives of Otolaryngology - Head and Neck Surgery, 130(10): 1191-1196, 2004.
Grikscheit TC, Siddique A, Ochoa ER, Srinivasan A, Alsberg E, Holden RA, Vacanti JP: Tissue-engineered small intestine improves recovery after massive small bowel resection. Annals of Surgery, 240(5): 748-754, 2004.
Simmons CA*, Alsberg E*, Hsiong S, Kim WJ, Mooney DJ: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 35(2): 562-569, 2004. *Shared first authorship.
Thornton AJ, Alsberg E, Hill EE, Mooney DJ: Shape retaining injectable hydrogels for minimally invasive bulking. Journal of Urology, 172(2): 763-768, 2004.
Thornton AJ, Alsberg E, Albertelli M, Mooney DJ: Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 77(12): 1798-1803, 2004.
2003
Alsberg E, Kong HJ, Hirano Y, Smith MK, Albeiruti A, Mooney DJ: Regulating bone formation via controlled scaffold degradation. Journal of Dental Research,82(11): 903-908, 2003.
Grikscheit TC, Ochoa ER, Ramsanahie A, Alsberg E, Mooney DJ, Whang EE, Vacanti JP: Tissue engineered large intestine resembles native colon with appropriate in vitro physiology and architecture. Annals of Surgery, 238(1): 35-41, 2003.
2002
Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ: Engineering growing tissues. Proceedings of the National Academy of Sciences, 99(19): 12025-12030, 2002.
Grikscheit TC, Ogilvie JB, Ochoa ER, Alsberg E, Mooney DJ, Vacanti, JP: Tissue-engineered colon exhibits function in vivo. Surgery, 132(2): 200-204, 2002.
2001
Alsberg E, Anderson KW, Albeiruti A, Franceschi RT, Mooney DJ: Cell-interactive alginate hydrogels for bone tissue engineering. Journal of Dental Research, 80(11): 2025-29, 2001.
Lee KY, Alsberg E, Mooney DJ: Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering. Journal of Biomedical Materials Research-A, 56(2): 228-33, 2001.
Bouhadir KH, Alsberg E, Mooney DJ: Hydrogels for combination delivery of antineoplastic agents. Biomaterials, 22(19): 2625-33, 2001.
Bouhadir KH, Lee KY, Alsberg E, Damm KL, Anderson KW, Mooney DJ: Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnology Progress, 17(5): 945-50, 2001.
Alsberg E, Hill EE, Mooney DJ: Craniofacial tissue engineering. Critical reviews in oral biology and medicine, 12(1): 64-75, 2001.
2000
Brown AN, Kim BS, Alsberg E, Mooney DJ: Combining chondrocytes and smooth muscle cells to engineer hybrid soft tissue constructs. Tissue Engineering, 6(4): 297-305, 2000.
1999
Richards M, Wineman AS, Alsberg E, Goulet JA, Goldstein SA: Viscoelastic characterization of mesenchymal gap tissue and consequences for tension accumulation during distraction. J. Biomech. Eng., 121: 116-123, 1999.
Tuftee C, Alsberg E, Ozbolat IT, Rizwan M. Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs. Trends in Biotechnology (in press 2023).
Hwang S-W, Lim C-M, Huynh CT, Moghimianavval H, Kotov NA, Alsberg E*, Liu AP*. Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation. Angewandte Chemie (in press 2023). *Co-corresponding authors.
Kang S-Y, Kimura M, Shrestha S, Lewis P, Lee S, Cai Y, Joshi P, Acharya P, Liu J, Yang Y, Sanchez JG, Ayyagari S, Alsberg E, Wells JM, Takebe T, Lee M-Y. A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis. Advanced Healthcare Materials (in press 2023).
Martyniak K, Cruz MA, Kennedy S, Karimzadeh M, Jeon O, Alsberg E, Kean TJ. Optimizing bioink composition for human chondrocyte expression of lubricin. Bioengineering (in press 2023).
Hsu Y-Y, Hwang S-W, Chen SJ, Alsberg E, Liu AP. Development of mechanosensitive synthetic cells for biomedical applications. SLAS Technology (in press 2023).
Hassan S, Wang T, Shi K, Huang Y, Urbina M, Gan K, Chen M, Willemen N, Kalam H, Luna-Ceron E, Cecen B, Elbait GD, Li J, Garcia-Rivera LE, Gurian M, Banday MM, Yang K, Lee MC, Zhuang W, Johnbosco C, Jeon O, Alsberg E, Leijten J, Shin SR. Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells. Biomaterials (in press 2023).
Margolis EA, Friend NE, Rolle MW, Alsberg E, Putnam AJ. Manufacturing the Multiscale Vascular Hierarchy: Progress Towards Solving Tissue Engineering’s Grand Challenge. Trends in Biotechnology (in press 2023).
Habib M, Hussien S, Jeon O, Lotz JC, Wu P I-K, Alsberg E, Fields AJ. Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition. Frontiers in Bioengineering and Biotechnology (in press, 2023).
Tang R, Gasvoda K, Alsberg E. Protein conformation stabilized by newly formed turns for thermal resilience. Biophysical Journal, 122(1): 82-89, 2023.
2022
Lee J, Jeon O, Koh J, Kim H-J, Lee SJ, Zhu Y, Song J, Lee Y, Nasiri R, Lee K, Bandaru P, Cho H-J, Zhang S, Barros NR, Ahadian S, Kang H, Dokmeci MR, Lee J, Di Carlo D, Alsberg E*, Khademhosseini A*. Micromechanical property mismatch between pericellular and extracellular matrices regulates stem cell articular and hypertrophic chondrogenesis. Matter (in press, 2022). *Co-corresponding authors.
Ding A, Lee SJ, Tang R, Gasvoda KL, He Felicia, Alsberg E. 4D cell-condensate bioprinting. Small, 18(36), e2202196, 2022. Yazdanpanah G, Shen X, Nguyen T, Anwar KN, Jeon O, Jiang Y, Pachenari M, Pan Y, Shokuhfar T, Rosenblatt MI, Alsberg E, Djalilian AR. A tunable extracellular matrix hydrogel for in-situ suture-free corneal repair. Advanced Functional Materials, 32(24): 2113383, 2022.
Ding A, Jeon O, Cleveland D, Gasvoda KL, Wells D, Lee SJ, Alsberg E. Jammed Micro-Flake Hydrogel for Four-Dimensional Living Cell Bioprinting. Adv Mater. 2022 Jan 22:e2109394.
Ding A, Lee SJ, Ayyagari S, Tang R, Huynh CT, Alsberg E. 4D biofabrication via instantly generated graded hydrogel scaffolds. Bioactive materials. 2022 Jan 1;7:324-32.
2021
Jeon O, Lee YB, Lee SJ, Guliyeva N, Lee J, Alsberg E. Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries. Bioactive Materials. 2021 Dec 22.
Jeon O, Kim TH, Alsberg E. Reversible dynamic mechanics of hydrogels for regulation of cellular behavior. Acta Biomaterialia. 2021 Dec 1;136:88-98.
Freeman FE, Pitacco P, Van Dommelen LH, Nulty J, Browe DC, Shin JY, Alsberg E, Kelly DJ. Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects. Bio-protocol. 2021 Nov 5;11(21):e4219-.
Lee YB, Jeon O, Lee SJ, Ding A, Wells D, Alsberg E. Induction of Four‐Dimensional Spatiotemporal Geometric Transformations in High Cell Density Tissues via Shape‐Changing Hydrogels. Advanced Functional Materials. 2021 Jun;31(24):2010104.
Ding A, Jeon O, Tang R, Lee YB, Lee SJ, Alsberg E. Cell‐Laden Multiple‐Step and
Reversible 4D Hydrogel Actuators to Mimic Dynamic Tissue Morphogenesis. Advanced Science. 2021 May;8(9):2004616.
Nulty J, Freeman FE, Browe DC, Burdis R, Ahern DP, Pitacco P, Lee YB, Alsberg E, Kelly DJ. 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects. Acta Biomaterialia. 2021 May 1;126:154-69.
McMillan A, Nguyen MK, Huynh CT, Sarett SM, Ge P, Chetverikova M, Nguyen K, Grosh D, Duvall CL, Alsberg E. Hydrogel microspheres for spatiotemporally controlled delivery of RNA and silencing gene expression within scaffold-free tissue engineered constructs. Acta Biomaterialia. 2021 Apr 1;124:315-26.
Tang R, Gasvoda K, Rabin J, Alsberg E. Transforming growth factor-β1 is resilient to heat-induced conformational change. Biological and Medicinal Chemistry. 2021 Mar
2020
Herberg S, Varghai D, Alt DS, Dang PN, Park H, Cheng Y, Shin JY, Dikina AD, Boerckel JD, Rolle MW, Alsberg E. Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration. Communications biology. 2021 Jan 19;4(1):1-6.
Tang R, Umemori K, Rabin J, Alsberg E. Bifunctional Nanoparticle‐Stabilized Hydrogel Colloidosomes Serve as both Extracellular Matrix and Bioactive Factor Delivery Vehicles. Advanced therapeutics. 2020 Nov;3(11):2000156.
Freeman FE, Pitacco P, van Dommelen LH, Nulty J, Browe DC, Shin JY, Alsberg E, Kelly DJ. 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration. Science Advances. 2020 Aug 1;6(33):eabb5093.
Sattayaprasert P, Vasireddi SK, Bektik E, Jeon O, Hajjiri M, Mackall JA, Moravec CS, Alsberg E, Fu J, Laurita KR. Human Cardiac Mesenchymal Stem Cells Remodel in Disease and Can Regulate Arrhythmia Substrates. Circulation: Arrhythmia and Electrophysiology. 2020 Jun 23.
Critchley S, Sheehy EJ, Cunniffe G, Diaz-Payno P, Carroll SF, Jeon O, Alsberg E, Brama PA, Kelly DJ. 3D printing of fiber-reinforced cartilaginous templates for the regeneration of osteochondral defects. Acta Biomaterialia. 2020 Jun 4.
Lee J, Jeon O, Kong M, Abdeen AA, Shin JY, Lee HN, Lee YB, Sun W, Bandaru P, Alt DS, Lee K, Kim HJ, Lee SJ, Chaterji S, Shin SR, Alsberg E, Khademhosseini A. Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell–based cartilage tissue engineering. Science Advances. 2020 May 1;6(21):eaaz5913.
Hung BP, Gonzalez-Fernandez T, Lin JB, Campbell T, Lee YB, Panitch A, Alsberg E, Leach JK. Multi-peptide presentation and hydrogel mechanics jointly enhance therapeutic duo-potential of entrapped stromal cells. Biomaterials. 2020 Mar 20:119973.
2019
de Melo BA, Jodat YA, Mehrotra S, Calabrese MA, Kamperman T, Mandal BB, Santana MH, Alsberg E, Leijten J, Shin SR. 3D Printed Cartilage‐Like Tissue Constructs with Spatially Controlled Mechanical Properties. Advanced Functional Materials. 2019 Dec;29(51):1906330.
Khalil AS, Yu X, Dang PN, Alsberg E, Murphy WL. A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates. Acta Biomaterialia. 2019 Sep 1;95:408-17.
Nguyen MK, Huynh CT, Gilewski A, Wilner SE, Maier KE, Kwon N, Levy M, Alsberg E. Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing. Science Advances. 2019 Aug 1;5(8):eaax0801.
Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin JY, McMillan A, Dikina AD, He F, Lee YB, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD, Alsberg E. Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair. Science Advances. 2019 Aug 1;5(8):eaax2476.
McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science Translational Medicine. 2019 Jun 5;11(495).
Jeon O, Lee YB, Hinton TJ, Feinberg AW, Alsberg E. Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues. Materials Today Chemistry. 2019 Jun 1;12:61-70.
Kudva AK, Dikina AD, Luyten FP, Alsberg E, Patterson J. Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture. Acta Biomaterialia. 2019 May 1;90:287-99.
Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TL, Kelly DJ. Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells. Acta Biomaterialia. 2019 Apr 1;88:314-24.
Capeling MM, Czerwinski M, Huang S, Tsai YH, Wu A, Nagy MS, Juliar B, Sundaram N, Song Y, Han WM, Takayama S, Alsberg E, Garcia AJ, Helmrath M, Putnam AJ, Spence JR. Nonadhesive alginate hydrogels support growth of pluripotent stem cell-derived intestinal organoids. Stem Cell Reports. 2019 Feb 12;12(2):381-94.
Critchley S, Cunniffe G, O'Reilly A, Diaz-Payno P, Schipani R, McAlinden A, Withers D, Shin J, Alsberg E, Kelly DJ. Regeneration of osteochondral defects using developmentally inspired cartilaginous templates. Tissue Engineering Part A. 2019 Feb 1;25(3-4):159-71.
Jeon O, Lee YB, Jeong H, Lee SJ, Wells D, Alsberg E. Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineered tissues with complex geometries. Materials Horizons. 2019;6(8):1625-31.
2018
Strobel HA, Qendro EI, Alsberg E, Rolle MW. Targeted delivery of bioactive molecules for vascular intervention and tissue engineering. Frontiers in pharmacology. 2018 Nov 21;9:1329.
Strobel HA, Hookway TA, Piola M, Fiore GB, Soncini M, Alsberg E, Rolle MW. Assembly of tissue-engineered blood vessels with spatially controlled heterogeneities. Tissue Engineering Part A. 2018 Oct 1;24(19-20):1492-503.
Nguyen MK, Jeon O, Dang PN, Huynh CT, Varghai D, Riazi H, McMillan A, Herberg S, Alsberg E. RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomaterialia. 2018 Jul 15;75:105-14.
Huynh CT, Liu F, Cheng Y, Coughlin KA, Alsberg E. Thiol-epoxy “Click” chemistry to engineer cytocompatible PEG-based hydrogel for siRNA-mediated osteogenesis of hMSCs. ACS Applied Materials & Interfaces. 2018 Jul 9;10(31):25936-42.
Jeon O, Lee K, Alsberg E. Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location‐Specific Regulation of Cellular Behaviors. Small. 2018 Jun;14(25):1800579.
Wong SA, Rivera KO, Miclau III T, Alsberg E, Marcucio RS, Bahney CS. Microenvironmental regulation of chondrocyte plasticity in endochondral repair—a new frontier for developmental engineering. Frontiers in Bioengineering and Biotechnology. 2018 May 15;6:58.
Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E. A modular strategy to engineer complex tissues and organs. Advanced Science. 2018 May;5(5):1700402.
Wang S, Bruning A, Jeon O, Long F, Alsberg E, Choi CK. An in-situphotocrosslinking microfluidic technique to generate non-spherical, cytocompatible, degradable, monodisperse alginate microgels for chondrocyte encapsulation. Biomicrofluidics. 2018;12(1):014106.
Herberg S, Varghai D, Cheng Y, et al. High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue. Nanotheranostics. 2018;2(2):128-143.
Seo J, Shin JY, Leijten J, Jeon O, Bal ÖA, Rouwkema J, Li Y, Shin S, Hajiali H, Alsberg E*, Khademhosseini E*: Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three-dimensions. ACS Applied Materials & Interfaces (in press, 2018). *Co-corresponding authors.
Seo J, Shin JY, Leijten J, Jeon O,Camci-Unal G, Dikina AD, Brinegar K, Ghaemmaghami AM, Alsberg E*, Khademhosseini A*: High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153: 85-101-255, 2018. *Co-corresponding authors.
McMillan A, Nguyen MK, Gonzalez-Fernandez T, Ge P, Yu X, Murphy WL, Kelly DJ, Alsberg E: Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials, 161: 240-255, 2018.
Wang S, Bruning A, Jeon O, , Long F, Alsberg E, Choi CK: An in-situ photocrosslinking microfluidic technique to generate non-spherical, cytocompatible, degradable, monodisperse alginate microgels for chondrocyte encapsulation. Biomicrofluidics, 12(1):014106, 2018.
2017
Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E: A modular strategy to engineer complex tissues and organs. Advanced Science (in press, 2017).
Jeon O, Shin JY, Marks R, Hopkins M, Kim TH, Park H, Alsberg E: Highly elastic and tough interpenetrating polymer network-structured hybrid hydrogels for cyclic mechanical loading-enhanced tissue engineering. Chemistry of Materials (in press, 2017).
Radisic M, Alsberg E: Special Issue on Tissue Engineering. ACS Biomaterials Science and Engineering, 3(9): 1880-1883, 2017.
Dang PN, Herberg S, Varghai D, Riazi H, Varghai D, McMillan A, Awadallah A, Phillips LM, Jeon O, Nguyen MK, Dwivedi N, Yu X, Murphy WL, Alsberg E: Endochondral ossification in critical-sized bone defects via readily implantable scaffold-free stem cell constructs. Stem Cells Translational Medicine, 6(7): 1644-1659, 2017.
Marcucio RS, Qin L, Alsberg E, Boerckel JD: Reverse engineering development: crosstalk opportunities between developmental biology and tissue engineering. Journal of Orthopaedic Research, 35(11): 2356-2368, 2017.
Dikina AD, Lai BP, Cao M, Zborowski M, Alsberg E: Magnetic field application or mechanical stimulation via magnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheets. Biomaterials Science, 5(7): 1241-1245, 2017.
Gelberman RH, Linderman SW, Jayaram R, Dikina AD, Sakiyama-Elbert S, Alsberg E, Thomopolous S, Shen H: Combined administration of ASCs and BMP12 promotes an M2 macrophage phenotype and enhances regeneration in tendon repair. Clinical Orthopaedics and Related Research, 475(9), 2318-2331, 2017.
Almeida H, Dikina A, Mulhall K, O'Brien F, Alsberg E, Kelly, D: Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells. ACS Biomaterials Science and Engineering, 3(6): 1075-1082, 2017.
Cunniffe GM, Gonzalez-Fernandez T, Daly A, Sathy BN, Jeon O, Alsberg E, Kelly DJ: 3D Bioprinting of PCL Reinforced Gene Activated Bioinks for Bone Tissue Engineering Tissue Engineering, Part A, 23(17-18): 891-900, 2017.
Dikina AD, Almeida HV, Cao M, Kelly DJ, Alsberg E: Scaffolds derived from ECM produced by chondrogenically-induced human MSC condensates support human MSC Chondrogenesis. ACS Biomaterials, 3(7): 1426-1436, 2017. Invited for special themed issue “Biomimetic Bioactive Materials: The Next Generation of Implantable Devices.”
Strobel HA, Dikina AD, Levi K, Solorio LD, Alsberg E, Rolle MW: Cellular self-assembly with microsphere incorporation for growth factor delivery within engineered vascular rings. Tissue Engineering A, 23(3-4): 143-155, 2017.
Fu AS, Solorio LD, Alsberg E, Saidel GM: Mathematical modeling of glycosaminoglycan production by stem cell aggregates incorporated with growth factor-releasing polymer microspheres. Journal of Tissue Engineering and Regenerative Medicine, 11(2): 481-488, 2017.
Sathy BN, Olvera D, Gonzalez-Fernandez T, Cunniffe GM, Pentlavalli S, Chambers P, Jeon O, Alsberg E, McCarthy HO, Dunne N, Donahue TLH, Kelly DJ: RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo. Journal of Material Chemistry B, 5:1753-1764, 2017.
Huynh CT, Zheng Z, Nguyen MK; McMillan A, Tonga GY, Rotello V, Alsberg E: Cytocompatible Catalyst-free Photodegradable Hydrogels for Light-Mediated RNA Release to Induce hMSC Osteogenisis. ACS Biomaterials Science and Engineering, 3(9): 2011-2023. Invited for special themed issue “Tissue Engineering.”
Nguyen MK, McMillan A, Schapira DS, Alsberg E: Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation. Journal of Material Chemistry B, 5: 485-495, 2017. Invited for special themed issue “Bio-inspired and Natural Materials.”
2016
Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA, Leach JK: Bone morphogenetic protein-2 promotes human mesenchymal stem cell survival and resultant bone formation when entrapped in photocrosslinked alginate hydrogels. Advanced Healthcare Materials, 5(19): 2501-2509, 2016.
Huynh CT, Nguyen MK, Tonga GY, Longe L, Rotello VM, Alsberg E: Photocleavable hydrogels for light-triggered siRNA release. Advanced Healthcare Materials, 5(3):305-10, 2016. Highlighted as cover.
Verrier S, Alini M, Alsberg E, Buchman SR, Kelly D, Laschke MW, Menger MD, Murphy WL, Stegemann JP, Schutz M, Miclau T, Stoddart MJ, Evans C: Tissue engineering and regenerative approaches to improving the healing of large bone defects. eCells and Materials, 32:87-110, 2016.
Carlier A, Alsberg E: Harnessing topographical cures for tissue engineering. Tissue Engineering A, 22(15-16): 995-6, 2016.
Daly AC, Cunniffe GM, Sathy BN, Jeon O, Alsberg E, Kelly DJ: 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering. Advanced Healthcare Materials, 5(18): 2353-62, 2016.
Huynh CT, Nguyen MK, Naris M, Tonga GY, Rotello VM, Alsberg E: Light-Triggered RNA Release and Induction of hMSC Osteogenesis via Photodegradable, Dual-Crosslinked Hydrogels. Nanomedicine, 11(12): 1535-50, 2016.
Jeon O, Marks R, Wolfson D, Alsberg E: Dual-crosslinked hydrogel microwell system for formation and culture of multicellular human adipose-derived stem cell spheroids. Journal of Material Chemistry B, 4: 3526-3533, 2016. Highlighted as inside front cover.
Samorezov JE, Headley EB, Everett CR, Alsberg E: Sustained presentation of BMP-2 enhances osteogenic differentiation of human adipose-derived stem cells in gelatin hydrogels. Journal of Biomedical Materials Research-A, 104(6):1387-97, 2016.
Wang S, Jeon O, Shankles PG, Liu Y, Alsberg E, Retterer ST, Lee BP, Choi CK: In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel. Biomicrofluidics, 10(1):011101, 2016.
Dang PN, Dwivedi N, Yu X, Phillips L, Bowerman C, Murphy W, Alsberg E: Guiding chondrogenesis and osteogenesis with mineral-coated hydroxyapatite and BMP-2 incorporated within high-density hMSC aggregates for bone regeneration. ACS Biomaterials, 2(1): 30-42, 2016. Highlighted as cover.
Dang PN, Dwivedi N, Phillips L, Yu X, Herberg S, Bowerman C, Solorio LD, Murphy WL, Alsberg E: Controlled growth factor delivery from microparticles incorporated within hMSC aggregates for enhanced bone tissue engineering via endochondral ossification. Stem Cells Translational Medicine, 5(2) 206-17, 2016.
Huynh CT, Nguyen MK, Tonga GY, Longe L, Rotello VM, Alsberg E: Photocleavable hydrogels for light-triggered siRNA release. Advanced Healthcare Materials, 5(3):305-10, 2016. Highlighted as cover.
2015
Solorio LD, Phillips LM, McMillan A, Cheng CW, Dang PN, Samorezov JE, Alsberg E: Spatially Organized Differentiation of Mesenchymal Stem Cells within Biphasic Microparticle-Incorporated High Cell Density Osteochondral Tissues. Advanced Healthcare Materials, 4(15):2306-13, 2015.
Samorezov JE, Morlock CM, Alsberg E: Dual ionic and photocrosslinked alginate hydrogels for micropatterned spatial control of material properties and cell behavior. Bioconjugate Chemistry, 26(7): 1339-47, 2015. Invited for special issue “Biofunctional Biomaterials – The 3rd Generation of Medical Devices.”
Dikina AD, Strobel HA, Lai BP, Rolle MW, Alsberg E: Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs. Biomaterials, 52: 452-62, 2015.
Jeon O, Wolfson DW, Alsberg E: In situ forming growth factor-loaded coacervate microparticle-embedded hydrogel for directing encapsulated stem cell fate. Advanced Materials, 27(13) 2216-23, 2015. Highlighted as Frontispiece.
Hill MC, Nguyen MK, Jeon O, Alsberg E: Spatial control of cell gene expression by siRNA gradients in biodegradable hydrogels. Advanced Healthcare Materials, 4(5): 714-22, 2015. Highlighted as Back Cover.
Samorezov JE, Alsberg E: Spatial regulation of controlled bioactive factor delivery for bone tissue engineering. Advanced Drug Delivery Reviews, 84: 45-67, 2015.
2014
Boerckel JD, Mason DE, McDermott AM, Alsberg E: Microcomputed tomography: Approaches and applications in bioengineering. Stem Cell Research & Therapy, 5(6): 144, 2014.
Jeong SI, Burns NA, Bonino CA, Kwon IK, Khan SA, Alsberg E: Improved cell infiltration of highly porous 3D nanofibrous scaffolds formed by combined fiber-fiber charge repulsions and ultra-sonication. Journal of Materials Chemistry B, 2(46): 8116-8122, 2014.
Nguyen K, Jeon O, Krebs MD, Alsberg E: Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation. Biomaterials, 35(24): 6278-86, 2014.
Dang PN, Solorio LD, Alsberg E: Driving cartilage formation in high-density human adipose-derived stem cell aggregate and sheet constructs without exogenous growth factor delivery. Tissue Engineering A, 20(23-24): 3163-75, 2014.
Yu X, Dang PD, Alsberg E, Murphy WL: Multilayer inorganic microparticles for tunable dual growth factor delivery. Advanced Functional Materials, 24(20): 3082-3093, 2014.
Nguyen K, Alsberg E: Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine. Progress in Polymer Science, 39(7): 1236-1265, 2014.
Cheng C, Solorio LD, Alsberg E: Decellularized tissues for orthopaedic tissue engineering. Biotechnology Advances, 32(2):462-84, 2014.
Panda NC, Zuckerman ST, Mesubi OO, Rosenbaum DS, Penn MS, Donahue JK, Alsberg E, Laurita KR: Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. J Interv Card Electrophysiol., 41(2):117-27, 2014.
Jeon O, Samorezov J, Alsberg E: Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications. Acta Biomaterialia, 10(1):47-55, 2014.
Andersen T, Markussen C, Dornish M, Heier-Baardson H, Melvik JE, Alsberg E, Christensen BE: In situ gelation for cell immobilization and culture in alginate foam scaffolds. Tissue Engineering, Part A, 20(3-4)600-10, 2014.
Andersen T, Melvik J, Gåserød O, Alsberg E, Christensen B: Ionically gelled alginate foams: Physical properties controlled by type, amount and source of gelling ions. Carbohydrate Polymers, 99:249-56, 2014.
Heylman CM, Santosa S, Krebs MD, Saidel GM, Alsberg E, Muschler GF: Modeling and experimental methods to predict optimal oxygen distribution for tissue regeneration in bone defects Medical and Biological Computing and Engineering, 52(4):321-30, 2014.
2013
Jeon O, Alt D, Ahmed SM, Linderman S, Alsberg E: Biochemical and physical signal gradients in hydrogels to control stem cell behavior. Advanced Materials, 25(44):6366-72, 2013.
Jeon O, Alsberg E: Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system. Advanced Functional Materials, 23(38):4765-75, 2013.
Saquing C, Tang C, Monian B, Bonino C, Manasco J, Alsberg E, Khan S: Alginate-PEO blend nanofibers and the role of carrier polymer in electrospinning. Industrial & Engineering Chemistry Research, 52(26):8692-8704, 2013.
Jeon O, Alsberg E: Photofunctionalization of alginate hydrogels to promote adhesion and proliferation of human mesenchymal stem cells. Tissue Engineering, Part A, 19(11-12):1424-32, 2013.
Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z: Imaging early stage osteogenic differentiation of mesenchymal stem cells. Journal of Orthopaedic Research, 31(6):871-9, 2013.
Solorio L, Vieregge E, Dhami C, Alsberg E: High density cell systems incorporating polymer microspheres as microenvironmental regulators in engineering cartilage tissues. Tissue Engineering, Part B, 19(3):209-20, 2013.
Nguyen K, Dang PN, Alsberg E: Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells. Acta Biomaterialia, 9(1): 4487-4495, 2013.
2012
Andersen T, Melvik J, Gåserød O, Alsberg E, Christensen B: Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters. Biomacromolecules, 13(11): 3703-3710, 2012.
Jeong SI, Jeon O, Krebs MD, Hill MC, Alsberg E: Biodegradable photocrosslinked alginate nanofiber scaffolds with tunable physical properties, cell adhesivity, and growth factor release. eCells and Materials, 24: 331-343, 2012.
Solorio LD, Vieregge EL, Dhami CD, Alsberg: Spatiotemporal regulation of chondrogenic differentiation with controlled delivery of TGF-β1 from gelatin microspheres in mesenchymal stem cell aggregates. Stem Cells Translational Medicine, 1(8): 632-639, 2012.
Chim H, Miller E, Gliniak C, Alsberg E: Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding. Cell and Tissue Research, 350(1): 89-94, 2012.
Bonino CA, Efimenko K, Jeong SI, Krebs MD, Alsberg E, Khan SA: Three-Dimensional Electrospun Alginate Mats via Tailored Charge Repulsions. Small, 8(12): 1928-36, 2012.
Jeon O, Alt D, Ahmed SM, Alsberg E: The effect of oxidation on the degradation of photocrosslinkable alginate hydrogels. Biomaterials, 33(13): 3503-3514, 2012.
Solorio LD, Vieregge EL, Dhami CD, Dang PN, Alsberg E: Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing chondrogenic growth factor. Journal of Controlled Release, 158(2): 224-232, 2012.
Lee Z, Dennis J, Alsberg E, Krebs MD, Welter J, Caplan A: Imaging stem cell differentiation for cell-based tissue repair. Methods Enzymol., 506:247-63, 2012.
2011
Bonino CA, Samerozev JE, Jeon O, Alsberg E, Khan SA: Real-time in situ rheology of alginate hydrogel photocrosslinking. Soft Matter, 7(24): 11510-11517, 2011.
Lee JB, Jeong SI, Bae MS, Heo DN, Kim CH, Alsberg E, Kwon IK: Highly porous electrospun nanofibers enhanced by ultra-sonication for improved cellular infiltration. Tissue Engineering Part A, 17(21-22): 2695-2702, 2011.
Jeon O, Powell C, Solorio L, Krebs MD, Alsberg E: Affinity-based growth factor delivery from biodegradable, photocrosslinked heparin-alginate hydrogels.Journal of Controlled Release, 154(3): 258-266, 2011.
Bonino CA, Krebs MD, Saquing CD, Jeong SI, Shearer KL, Alsberg E, Khan SA: Electrospinningalginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems. Carbohydrate Polymers, 85(1): 111-119, 2011.
Jeon O, Krebs MD, Alsberg E: Controlled and sustained gene delivery from injectable porous PLGA scaffolds. Journal of Biomedical Materials Research-A,98A(1): 72-79, 2011.
Krebs MD, Alsberg E: Localized, Targeted and Sustained Silencing RNA Delivery.Chemistry - A European Journal,17(11): 3054-3062, 2011.
Jeong SI, Krebs MD, Bonino CA, Samorezov JE, Khan SA, Alsberg E: Electrospun chitosan-alginate nanofibers with in situ polyelectrolyte complexation for use as tissue engineering scaffolds. Tissue Engineering: Part A, 17(1-2): 59-70, 2011.
2010
Sasaki JI, Asoh TA, Matsumoto T, Egusa H, Yatani H, Akashi M, Alsberg E, Sohmura T: Fabrication of 3D cell constructs using temperature-responsive hydrogel. Tissue Engineering: Part A, 16(8): 2497-2504, 2010.
Jeon O, Powell C, Ahmed SM, Alsberg E: Biodegradable, photocrosslinked alginate hydrogels with independently tailorable physical properties and cell adhesivity. Tissue Engineering: Part A, 16(9): 2915-2925, 2010.
Jeong SI, Krebs MD, BoninoCA, KhanSA, AlsbergE: Electrospun alginate nanofibers with controlled cell adhesion for tissue engineering. Macromolecular Biosciences, 10(8): 934-943, 2010.
Solorio LD, Fu AS, Hernandez-Irizarry R, Alsberg E: Chondrogenic differentiation of human mesenchymal stem cell aggregates via controlled release of TGF-b1 from incorporated polymer microspheres. Journal of Biomedical Materials Research-A, 92(3): 1139-1144, 2010.
Krebs MD, Salter E, Chen E, Sutter KA, Alsberg E: Calcium phosphate-DNA nanoparticle gene delivery from alginate hydrogels induces in vivo osteogenesis.Journal of Biomedical Materials Research-A, 92(3): 1131-1138, 2010.
2009
Erb RM, Krebs MD, Alsberg Em Samata B, Rotello VM, Yellen BB: Beyond diffusion-limited aggregation kinetics in microparticle suspensions. Physical Review E, 80(5 Pt 1), 2009.
Krebs MD, Jeon O, Alsberg E: Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels. Journal of the American Chemical Society, 131(26): 9204-9206, 2009.
Krebs MD, Erb RM, Yellen BB, Samanta B, Bajaj A, Rotello VM, Alsberg E: Formation of
ordered cellular structures in suspension via label-free negative magnetophoresis. Nanoletters, 9(5): 1812-1817, 2009.
Krebs MD, Sutter K, Lin AS, Guldberg RE, Alsberg E: Injectable poly(lactic-co-glycolic) acid scaffolds with in situ pore formation for tissue engineering. ActaBiomaterialia, 5(8): 2847-2759, 2009.
Jeon O, Mansour JM, Alsberg E: Photocrosslinkable alginate hydrogels with tunable biodegradation rates and mechanical properties. Biomaterials, 30(14): 2724-2734, 2009.
2008
Grikscheit TC, Sala FG, Ogilvie J, Bower KA, Ochoa ER, Alsberg E, Mooney DJ, Vacanti JP: Tissue-engineered spleen protects against overwhelming pneumococcal sepsis in a rodent model. Journal of Surgical Research, 149(2): 214-218, 2008.
2007
Matsumoto T, Sasaki JI, Alsberg E, Egusa H, Yatani H, Sohmura T: Three-dimensional cell and tissue patterning in a strained fibrin gel system. PLoS ONE,2(11): e1211, 2007.
2006
Alsberg E, von Recum HA, Mahoney MJ. Environmental cues to guide stem cell fate decision for tissue engineering applications. Expert Opinion on Biological Therapy, 6(9):847-866, 2006.
Alsberg E, Feinstein E, Joy MP, Prentiss M, Ingber DE: Magnetically-guided self-assembly of fibrin matrices with ordered nanoscale structure for tissue engineering. Tissue Engineering, 12(11): 3247-3256, 2006. (Chosen for cover)
Xia S, Hunt TP, Mayers BT, Alsberg E, Whitesides GM, Westervelt R, Ingber DE. Combined micromagnetic-microfluidic separation of living cells in continuous flow. Biomed. Microdevices, 8(4): 299-308, 2006.
2005
Overby DR, Matthews BD, Alsberg E, Ingber DE: Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomaterialia, 1(3): 295-303, 2005.
Lee H, Liu Y, Alsberg E, Ingber DE, Westervelt RM, Ham D: An IC/microfluidic hybrid microsystem for 2D magnetic manipulation of individual biological cells.IEEE Int. Solid State Circuits, 80-81, 2005.
Kong HJ, Polte TR, Alsberg E, Mooney DJ: FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proceedings of the National Academy of Sciences, 102(12): 4300-4305, 2005.
Moore KA, Polte T, Huang S, Shi B, Alsberg E, Sunday ME, Ingber DE: Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Developmental Dynamics, 232(2): 268-281, 2005.
2004
Lee KY*, Alsberg E*, Hsiong S, Mooney DJ: Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation. Nanoletters, 4(8): 1501-1506, 2004. *Shared first authorship.
Kong HJ, Alsberg E, Kaigler D, Lee KY, Mooney DJ: Controlling degradation of hydrogels via size of crosslinked junctions. Advanced Materials, 16(21): 1917-1921, 2004.
Grimmer JF, Gunnlaugsson CB, Alsberg E, Murphy HS, Kong HJ, Mooney DJ, Weatherly RA: Tracheal reconstruction using tissue-engineered cartilage.Archives of Otolaryngology - Head and Neck Surgery, 130(10): 1191-1196, 2004.
Grikscheit TC, Siddique A, Ochoa ER, Srinivasan A, Alsberg E, Holden RA, Vacanti JP: Tissue-engineered small intestine improves recovery after massive small bowel resection. Annals of Surgery, 240(5): 748-754, 2004.
Simmons CA*, Alsberg E*, Hsiong S, Kim WJ, Mooney DJ: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 35(2): 562-569, 2004. *Shared first authorship.
Thornton AJ, Alsberg E, Hill EE, Mooney DJ: Shape retaining injectable hydrogels for minimally invasive bulking. Journal of Urology, 172(2): 763-768, 2004.
Thornton AJ, Alsberg E, Albertelli M, Mooney DJ: Shape-defining scaffolds for minimally invasive tissue engineering. Transplantation, 77(12): 1798-1803, 2004.
2003
Alsberg E, Kong HJ, Hirano Y, Smith MK, Albeiruti A, Mooney DJ: Regulating bone formation via controlled scaffold degradation. Journal of Dental Research,82(11): 903-908, 2003.
Grikscheit TC, Ochoa ER, Ramsanahie A, Alsberg E, Mooney DJ, Whang EE, Vacanti JP: Tissue engineered large intestine resembles native colon with appropriate in vitro physiology and architecture. Annals of Surgery, 238(1): 35-41, 2003.
2002
Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ: Engineering growing tissues. Proceedings of the National Academy of Sciences, 99(19): 12025-12030, 2002.
Grikscheit TC, Ogilvie JB, Ochoa ER, Alsberg E, Mooney DJ, Vacanti, JP: Tissue-engineered colon exhibits function in vivo. Surgery, 132(2): 200-204, 2002.
2001
Alsberg E, Anderson KW, Albeiruti A, Franceschi RT, Mooney DJ: Cell-interactive alginate hydrogels for bone tissue engineering. Journal of Dental Research, 80(11): 2025-29, 2001.
Lee KY, Alsberg E, Mooney DJ: Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering. Journal of Biomedical Materials Research-A, 56(2): 228-33, 2001.
Bouhadir KH, Alsberg E, Mooney DJ: Hydrogels for combination delivery of antineoplastic agents. Biomaterials, 22(19): 2625-33, 2001.
Bouhadir KH, Lee KY, Alsberg E, Damm KL, Anderson KW, Mooney DJ: Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnology Progress, 17(5): 945-50, 2001.
Alsberg E, Hill EE, Mooney DJ: Craniofacial tissue engineering. Critical reviews in oral biology and medicine, 12(1): 64-75, 2001.
2000
Brown AN, Kim BS, Alsberg E, Mooney DJ: Combining chondrocytes and smooth muscle cells to engineer hybrid soft tissue constructs. Tissue Engineering, 6(4): 297-305, 2000.
1999
Richards M, Wineman AS, Alsberg E, Goulet JA, Goldstein SA: Viscoelastic characterization of mesenchymal gap tissue and consequences for tension accumulation during distraction. J. Biomech. Eng., 121: 116-123, 1999.